Labels:text | screenshot | black and white | black | document OCR: ximately At normal plasma concentrations, appr specific globulin ninety per cent of cortisol is bound to th binding protein - corticosteroid- binding rtisol is (CBG). The average production rate of c mainly by 20mg/d. Cortisol is metabolised rapidly the liver, and has a plasma half-life of learance approximately two hours; the metabolic formed by rate is 2001/d. The major metabolites ar groups to reduction of the double bond and keton rtisone, produce tetrahydrocortisol, tetrahydroco e excreted cortol, and cortolone (Fig. 7.13). These a ronic acid into the urine in conjugation with gluc venty per ation of and account for approximately sixty to s cent of the total cortisol produced. Estin e sample these steroids in a twenty-four-hour uri n rate of thus provides an estimate of the secreti to ...
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